Setien was named Barcelona coach late on Monday, tasked with the job of restoring the club's iconic passing style, but the appointment represents a huge gamble for the Catalans given the 61-year-old's lack of success at the highest level.
Unzue is one of the two leading candidates to succeed Luis Enrique, who announced this month he will leave at the end of this season, along with Athletic Bilbao coach Ernesto Valverde.
Barca won their fifth European Cup in 2015 and the signs of decline have been evident over the past five years since -- but no-one envisaged a fall as great as this.
News of all that transpired on and off the football field.
Messi, who won the Spanish La Liga title with Barcelona last season as well as the European golden boot having scored 54 goals in 58 games in all competitions, last won the award in 2015.
Barcelona will lodge a second appeal against the dismissal of coach Tito Vilanova in Sunday's 2-1 win at Osasuna after the Spanish soccer federation (RFEF) rejected an initial effort and suspended the coach for two games on Wednesday.
Barcelona's amazing 6-1 victory over Paris St Germain on Wednesday that sent them through to the Champions League quarter-finals will forever stay in the memories of supporters, coach Luis Enrique said.
Barcelona coach Luis Enrique said he believes Lionel Messi will sign a new contract with the Spanish champions despite reports the five times World Player of the Year is stalling over a new deal.
Holders Barcelona crashed out of the Champions League after being stifled by a brilliantly well-organised Atletico Madrid.
IMAGES from the Champions League matches played on Wednesday.
The enduring image of Luis Enrique for many soccer fans is the Spain player with blood gushing from his nose after a vicious elbow from Italy defender Mauro Tassotti during the 1994 World Cup quarter-final in Boston.
Roundup of the matches being held across major football leagues in Europe on Sunday
Barcelona are on the verge of Champions League elimination after being thrashed 3-0 by Juventus in Turin on Tuesday, and few believe lightning can strike twice.
A lacklustre Barcelona squandered the chance to go top of La Liga after crashing to a shock 1-0 home defeat by Malaga on Saturday.
Barcelona coach Luis Enrique is head strong but it appears as though he may be fighting a losing battle with the four times World Player of the Year.
Barcelona's famed youth academy has taken a back seat to big-name signings in recent years but as a result of the FIFA transfer ban imposed on the club, promising youngsters have been given a chance to shine in Luis Enrique's side.
News of all that's transpired on and off the football field
Round-up of football matches played around Europe on Saturday.
News of all that's transpired on and off the football field
The clinical Argentine Messi now has 11 goals in his last five games in all competitions and with record signing Ousmane Dembele injured and Luis Suarez rested, he put on a sensational show at Camp Nou to extend Barcelona's La Liga lead.
Messi stretched Barca's lead by finishing off a brilliant move with Luis Suarez in the 50th minute and the Uruguayan joined his close friend and strike partner on 15 league goals by robbing an Eibar defender and finishing inside the near post in the 68th.
Bayern Munich and coach Pep Guardiola will part ways after three seasons at the end of the current campaign and Italian Champions League-winning coach Carlo Ancelotti will replace the Spaniard, club Chief Executive Karl-Heinz Rummenigge said on Sunday.
UEFA has thrown out protests made by Real Madrid and Barcelona against each other following their ill-tempered Champions League semi-final first leg last week.
News of all that transpired on and off the field.
Barcelona midfielder Xavi will announce on Thursday he is leaving the club he joined as an 11-year-old to sign a lucrative three-year deal with Qatari side Al Sadd, his agent told Reuters on Wednesday.
Former Barcelona great Michael Laudrup lambasted the Brazil international for "provoking" the opposition in Saturday's 5-1 win at Leganes and Neymar's flamboyant style will be scrutinised again on Wednesday when Barcelona host Atletico.
Lionel Messi's father Jorge has sought to play down comments his son made this week which suggested the four-time World Player of the Year could consider leaving Barcelona.
'We will need to have a good day to get past a rival of this magnitude'
'Messi is a player that makes a difference in all games and in Clasicos he has always made a big impact but we will have to see if he is ready' 'You never know what can happen in these types of games and when you start as favourite it can often go wrong'
Real are unbeaten since February, winning 10 of their last 12 games. In contrast, Barcelona have won just two of their previous five in all competitions and were dumped out of Europe in midweek.
Real's Cristiano Ronaldo will be going in search of his third consecutive World Player of the Year award
The plane carrying Chapecoense to the Copa Sudamericana final, first leg against Atletico Nacional crashed into mountains outside Medellin, Colombia on November 28 after running out of fuel, killing 71 of the 77 people on board
Luuk de Jong's first-half header gave Barcelona a 1-0 win at Mallorca
Barcelona have been boosted by the successful return from injury of talismanic playmaker Andres Iniesta as they prepare to host city rivals Espanyol in La Liga on Sunday.
Ivan Toney, once Brentford's lynchpin in attack, has moved to Al-Ahli for 40 million pounds ($52.50 million).
IMAGES from the Champions League quarter-final played between Barcelona and Bayern Munich in Lisbon on Friday.
Barcelona thrashed Sporting Gijon 6-1 to go top of La Liga on a dramatic night in Spain on Wednesday as Luis Enrique announced he was stepping down as the Catalan club's coach at the end of the season.
Real Madrid's star striker Cristiano Ronaldo made up for his otherwise quiet night by scoring the winner to beat Barcelona 2-1 win at the CampNou in Barcelona on Saturday.
Barca coach, Luis Enrique says that all is well at Camp Nou and the team is united.
Real Madrid thrashed arch-rivals and league leaders Barcelona 4-0 to reach the Copa del Rey final